Endocrine Abstracts

Objective: One of the common features of hypothyroidism is weight gain or failure to lose weight. Also bradycardia and mild hypertension can be seen. Impact of thyroid hormone deficiency on glucose and insulin metabolism is not fully understood. Thyroid hormones play role in lipid synthesis, metabolism and mobilization. Metabolic syndrome is a state which most features of hypothyroidism can be seen. Our aim is to investigate the frequency of metabolic syndrome in hypothyroid p...

Objective: Thyroid hormones directly or indirectly, through erythropoietin, stimulate growth of erythroid colonies. Anemia is often the first sign of hypothyroidism. Hypothyroidism can lead to a wide variety (%20–60) of anemic disorders. Numerous mechanisms are involved in the pathogenesis of these anemias which can be microcytic, macrocytic and normocytic. Microcytic anemia is usually ascribed to malabsorption of iron and loss of iron by menorrhagia. Macrocytic anemia is...

Background: Diabetic foot ulcer and lower extremity amputation are leading causes of mortality and morbidity in diabetic patients. Diabetic neuropathy and peripheral vascular disease are major reasons for diabetic foot ulcer. Most of the studies showed that hyperhomocystinemia is related with microvascular and macrovascular complications in diabetic patients. Also hyperhomocysteinemia is related to poor ulcer healing. In this study, we investigated the relationship of hyperhom...

Objective: Diabetic foot ulcer is associated with increased morbidity and mortality. The most important factor related to the development of foot ulcer is peripheral neuropathy. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation, fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). TAFI may be involved in the mechanism of vascular endothelial damage in diabetic patients. The aim of th...